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Symbol
Name
ID

Kcnt1
potassium channel, subfamily T, member 1
MGI:1924627

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Spasticity

Gliosis

Delayed CNS myelination

Cerebral cortical atrophy

Hypoplasia of the corpus callosum

Neuronal loss in central nervous system

Clonus

Tetraplegia

Reduced eye contact

Depression

Psychosis

Atypical behavior

Personality disorder

Aggressive behavior

Intellectual disability

Hyperreflexia

Epileptic encephalopathy

Developmental regression

Profound global developmental delay

Focal-onset seizure

Focal motor seizure

Focal autonomic seizure

Generalized tonic seizure

Status epilepticus

Disease(s) Associated with KCNT1

autosomal dominant nocturnal frontal lobe epilepsy 5

developmental and epileptic encephalopathy 14

Mouse Phenotypes

nervous system phenotype

seizures

tonic seizures

tonic-clonic seizures

abnormal nervous system morphology

abnormal glutaminergic neuron morphology

abnormal nervous system electrophysiology

abnormal action potential

impaired ability to fire action potentials

abnormal GABAergic neuron physiology

abnormal sensory neuron physiology

abnormal CNS synaptic transmission

decreased channel response intensity

Availability

Mouse Genotype

Kcnt1^em1Nju/Kcnt1^em1Nju

Kcnt1^em1Pqt/Kcnt1^em1Pqt

Kcnt1^em8Frk/Kcnt1^em8Frk

*

Kcnt1^tm1.2Acsc/Kcnt1^tm1.2Acsc

Kcnt1^tm1.2Clin/Kcnt1^tm1.2Clin

Kcnt1^tm1Dgen/Kcnt1^tm1Dgen

*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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